Lars Edvinsson Selected Research

Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)

3/2019	Vascular pathology of large cerebral arteries in experimental subarachnoid hemorrhage: Vasoconstriction, functional CGRP depletion and maintained CGRP sensitivity.
8/2017	Proteomic Expression Changes in Large Cerebral Arteries After Experimental Subarachnoid Hemorrhage in Rat Are Regulated by the MEK-ERK1/2 Pathway.
2/2015	Regulation of microRNAs miR-30a and miR-143 in cerebral vasculature after experimental subarachnoid hemorrhage in rats.
2/2015	MEK1/2 inhibitor U0126 but not endothelin receptor antagonist clazosentan reduces upregulation of cerebrovascular contractile receptors and delayed cerebral ischemia, and improves outcome after subarachnoid hemorrhage in rats.
12/2014	CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediated vasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function.
5/2014	Role of unphosphorylated transcription factor STAT3 in late cerebral ischemia after subarachnoid hemorrhage.
3/2013	Early events triggering delayed vasoconstrictor receptor upregulation and cerebral ischemia after subarachnoid hemorrhage.
12/2012	Regulation of enhanced cerebrovascular expression of proinflammatory mediators in experimental subarachnoid hemorrhage via the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway.
6/2012	In vivo experimental stroke and in vitro organ culture induce similar changes in vasoconstrictor receptors and intracellular calcium handling in rat cerebral arteries.
1/2012	Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia.

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Lars Edvinsson Research Topics

Disease

102	Migraine Disorders (Migraine) 05/2024 - 01/2002
32	Brain Ischemia (Cerebral Ischemia) 01/2022 - 09/2002
31	Headache (Headaches) 01/2022 - 05/2002
22	Pain (Aches) 05/2024 - 09/2002
19	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 03/2019 - 01/2002
18	Inflammation (Inflammations) 05/2024 - 07/2004
18	Stroke (Strokes) 12/2022 - 04/2006
17	Cardiovascular Diseases (Cardiovascular Disease) 02/2021 - 01/2004
10	Ischemia 01/2022 - 06/2009
10	Ischemic Stroke 01/2022 - 04/2004
8	Cluster Headache (Cluster Headaches) 01/2020 - 05/2002
7	Infarction (Infarctions) 12/2022 - 01/2007
7	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2022 - 01/2007
7	Heart Failure 06/2020 - 01/2004
7	Angina Pectoris 02/2013 - 06/2006
6	Myocardial Ischemia (Ischemic Heart Diseases) 12/2018 - 01/2004
6	Atherosclerosis 02/2014 - 08/2002
5	Hypertension (High Blood Pressure) 01/2018 - 12/2004
4	Vascular Diseases (Vascular Disease) 06/2012 - 02/2002
3	Myocardial Infarction 10/2022 - 11/2007
3	Ganglion Cysts (Ganglion) 01/2019 - 01/2012
3	Intracranial Vasospasm 04/2004 - 01/2002
2	Facial Pain (Myofacial Pain) 05/2024 - 06/2015
2	Headache Disorders (Headache Syndromes) 01/2019 - 01/2019
2	Reperfusion Injury 10/2017 - 01/2017
2	Neurogenic Inflammation 01/2017 - 12/2010

Drug/Important Bio-Agent (IBA)

61	Calcitonin Gene-Related PeptideIBA 05/2024 - 01/2002
35	Endothelins (Endothelin)IBA 02/2021 - 01/2002
30	Calcitonin Gene-Related Peptide Receptors (Calcitonin-Gene Related Peptide Receptor)IBA 10/2022 - 05/2002
24	Calcitonin Gene-Related Peptide Receptor AntagonistsIBA 10/2022 - 01/2002
21	NeuropeptidesIBA 02/2022 - 05/2002
15	Tryptamines (Triptans)IBA 02/2022 - 05/2002
13	Peptides (Polypeptides)IBA 01/2022 - 07/2005
12	Vasoconstrictor AgentsIBA 01/2022 - 12/2004
12	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 10/2020 - 11/2011
12	U 0126 (UO 126)IBA 01/2019 - 04/2007
11	Endothelin Receptors (Endothelin Receptor)IBA 10/2017 - 05/2003
10	Monoclonal AntibodiesIBA 10/2022 - 01/2017
10	Serotonin (5 Hydroxytryptamine)IBA 02/2022 - 12/2007
10	SmokeIBA 02/2021 - 12/2008
9	Vasodilator Agents (Vasodilators)IBA 03/2019 - 07/2005
9	Messenger RNA (mRNA)IBA 01/2019 - 01/2004
9	Angiotensin IIIBA 01/2018 - 04/2004
9	Endothelin-1 (Endothelin 1)IBA 01/2018 - 09/2002
8	Proteins (Proteins, Gene)FDA Link 12/2022 - 01/2007
7	Neurotransmitter Agents (Neurotransmitter)IBA 12/2022 - 06/2003
7	Angiotensin Receptors (Angiotensin II Receptor)IBA 02/2010 - 10/2004
6	fremanezumabIBA 01/2023 - 11/2015
6	AntibodiesIBA 12/2019 - 08/2015
6	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 08/2017 - 12/2012
6	telcagepantIBA 09/2014 - 02/2008
5	Hormones (Hormone)IBA 02/2024 - 02/2020
5	Oxytocin (Pitocin)FDA LinkGeneric 02/2024 - 02/2020
5	CytokinesIBA 01/2020 - 02/2010
5	Adenylyl Cyclases (Adenylyl Cyclase)IBA 11/2018 - 12/2014
5	AngiotensinsIBA 01/2013 - 10/2004
5	Mitogen-Activated Protein KinasesIBA 12/2012 - 01/2008
4	salicylhydroxamic acid (SHAM)IBA 01/2023 - 09/2002
4	erenumabIBA 12/2019 - 01/2018
4	Thromboxane Receptors (Thromboxane Receptor)IBA 01/2017 - 02/2010
4	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))IBA 01/2017 - 05/2002
4	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 01/2016 - 07/2006
4	ThromboxanesIBA 01/2013 - 02/2008
4	Type 1 Angiotensin ReceptorIBA 05/2009 - 04/2004
4	olcegepantIBA 02/2008 - 01/2002
3	Freund's AdjuvantIBA 05/2024 - 01/2015
3	Protein Kinase CIBA 04/2024 - 01/2007
3	Gonadal Steroid Hormones (Sex Hormones)IBA 02/2024 - 10/2021
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 12/2022 - 10/2011
3	Substance PIBA 01/2021 - 07/2014
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 07/2006
3	Pituitary Adenylate Cyclase-Activating Polypeptide ReceptorsIBA 01/2020 - 08/2018
3	Protein Kinases (Protein Kinase)IBA 01/2019 - 05/2014
3	Islet Amyloid PolypeptideIBA 01/2016 - 07/2005
3	Sumatriptan (Imigran)FDA LinkGeneric 12/2014 - 01/2004
3	AdrenomedullinIBA 01/2014 - 07/2005
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2013 - 11/2007
3	5-HT1B Serotonin ReceptorIBA 01/2013 - 07/2003
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2011 - 12/2007
3	Endothelin B ReceptorIBA 03/2010 - 07/2004
2	incobotulinumtoxinA FDA Link 05/2024 - 01/2015
2	Type A Botulinum Toxins (Botox)FDA Link 05/2024 - 11/2018
2	Progesterone FDA LinkGeneric 02/2024 - 01/2022
2	Uridine Diphosphate (UDP)IBA 01/2022 - 02/2002
2	purinoceptor P2Y6IBA 01/2022 - 05/2003
2	rimegepant sulfateIBA 01/2021 - 01/2019
2	RNA (Ribonucleic Acid)IBA 12/2020 - 07/2007
2	ubrogepantIBA 01/2020 - 01/2018
2	MicroRNAs (MicroRNA)IBA 11/2019 - 02/2015
2	Purinergic Receptors (Receptors, Purine)IBA 10/2019 - 01/2014
2	galcanezumabIBA 01/2019 - 01/2018
2	Excitatory Amino Acid AntagonistsIBA 01/2019 - 12/2012
2	Retinaldehyde (Retinal)IBA 01/2019 - 01/2016
2	eptinezumabIBA 01/2019 - 01/2018
2	Adenosine Triphosphate (ATP)IBA 12/2018 - 07/2005
2	sarafotoxins s6IBA 01/2018 - 07/2004
2	Carbachol (Carbastat)FDA Link 01/2018 - 02/2013
2	Thromboxane A2 (A2, Thromboxane)IBA 01/2017 - 02/2010

Therapy/Procedure

29	Therapeutics 02/2024 - 06/2006
5	Counterpulsation (External Counterpulsation) 02/2013 - 06/2006